Expression profiling of prostate cancer tissue delineates genes associated with recurrence after prostatectomy.

ABSTRACT: Prostate cancer is a leading cause of cancer death amongst males. The main clinical dilemma in treating prostate cancer is the high number of indolent cases that confer a significant risk of overtreatment. In this study, we have performed gene expression profiling of tumor tissue specimens from 36 patients with prostate cancer to identify transcripts that delineate aggressive and indolent cancer. Key genes were validated using previously published data and by tissue microarray analysis. Two molecular subgroups were identified with a significant overrepresentation of tumors from patients with biochemical recurrence in one of the groups. We successfully validated key transcripts association with recurrence using two publically available datasets totaling 669 patients. Twelve genes were found

SUBMITTER: Mortensen MM 

PROVIDER: S-EPMC4629186 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature