Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study.

ABSTRACT:

Aims/hypothesis

Women with a history of gestational diabetes mellitus (GDM) are advised to control their weight after pregnancy. We aimed to examine how adiposity and weight change influence the long-term risk of developing type 2 diabetes after GDM.

Methods

We included 1,695 women who had incident GDM between 1991 and 2001, as part of the Diabetes & Women's Health study, and followed them until the return of the 2009 questionnaire. Body weight and incident type 2 diabetic cases were reported biennially. We defined baseline as the questionnaire period when women reported an incident GDM pregnancy. We estimated HRs and 95% CIs using Cox proportional hazards models.

Results

We documented 259 incident cases of type 2 diabetes during up to 18 years of follow-up. The adjus

SUBMITTER: Bao W 

PROVIDER: S-EPMC4629783 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature