Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension.

ABSTRACT:

Rationale

Inflammation and adaptive immunity play a crucial role in the development of hypertension. Angiotensin II and probably other hypertensive stimuli activate the central nervous system and promote T-cell activation and end-organ damage in peripheral tissues.

Objective

To determine if renal sympathetic nerves mediate renal inflammation and T-cell activation in hypertension.

Methods and results

Bilateral renal denervation using phenol application to the renal arteries reduced renal norepinephrine levels and blunted angiotensin II-induced hypertension. Bilateral renal denervation also reduced inflammation, as reflected by decreased accumulation of total leukocytes, T cells, and both CD4+ and CD8+ T cells in the kidney. This was associated with a marked reduction i

SUBMITTER: Xiao L 

PROVIDER: S-EPMC4629828 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature