A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex.

ABSTRACT: We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, transient responses to input (appropriate for sensory processing), whereas association areas integrate inputs over time and exhibit persistent activity (suitable for decision-making and working memory). The model displays multiple temporal hierarchies, as evidenced by contrasting responses to visual versus somatosensory stimulation. Moreover, slower prefrontal and temporal areas have a disproportionate impact on global brain dynamics. These findings establish a circuit mechanism

SUBMITTER: Chaudhuri R 

PROVIDER: S-EPMC4630024 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature