Endothelial cell sensing, restructuring, and invasion in collagen hydrogel structures.

ABSTRACT: Experimental tools to model cell-tissue interactions will likely lead to new ways to both understand and treat cancer. While the mechanical properties and regulation of invasion have been recently studied for tumor cells, they have received less attention in the context of tumor vascular dynamics. In this article, we have investigated the interaction between the surfaces of structures encountered by endothelial cells invading their surrounding extracellular matrix (ECM) during angiogenesis. For this purpose, we have fabricated round and sharp geometries with various curvature and sharpness indices in collagen hydrogel over a wide range of stiffness to mimic different microenvironments varying from normal to tumor tissues. We have then cultured endothelial cells on these structures to inves

SUBMITTER: Hosseini Y 

PROVIDER: S-EPMC4630156 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature