Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia.

ABSTRACT:

Importance

Hemispheric specialization of the human brain is a marker of successful neurodevelopment. Altered brain asymmetry that has been repeatedly reported in schizophrenia may represent consequences of disrupted neurodevelopment in the disorder. However, a complete picture of functional specialization in the schizophrenic brain and its connectional substrates is yet to be unveiled.

Objectives

To quantify intrinsic hemispheric specialization at cortical and subcortical levels and to reveal potential disease effects in schizophrenia.

Design, setting, and participants

Resting-state functional connectivity magnetic resonance imaging has been previously used to quantitatively measure hemispheric specialization in healthy individuals in a reliable manner. We quantified

SUBMITTER: Mueller S 

PROVIDER: S-EPMC4630217 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature