Role of the renal sympathetic nerve in renal glucose metabolism during the development of type 2 diabetes in rats.

ABSTRACT:

Aims/hypothesis

Recent clinical studies have shown that renal sympathetic denervation (RDX) improves glucose metabolism in patients with resistant hypertension. We aimed to elucidate the potential contribution of the renal sympathetic nervous system to glucose metabolism during the development of type 2 diabetes.

Methods

Uninephrectomised diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats underwent RDX at 25 weeks of age and were followed up to 46 weeks of age.

Results

RDX decreased plasma and renal tissue noradrenaline (norepinephrine) levels and BP. RDX also improved glucose metabolism and insulin sensitivity, which was associated with increased in vivo glucose uptake by peripheral tissues. Furthermore, RDX suppressed overexpression of sodium-glucose cotranspor

SUBMITTER: Rafiq K 

PROVIDER: S-EPMC4630257 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature