Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers.

ABSTRACT: Sleep-wake states are impaired in various neurological disorders. Impairment of sleep-wake states can be an early condition that exacerbates these disorders. Therefore, treating sleep-wake dysfunction may prevent or slow the development of these diseases. Although many gene products are likely to be involved in the sleep-wake disturbance, hypnotics and psychostimulants clinically used are limited in terms of their mode of action and are not without side effects. Therefore, there is a growing demand for developing new hypnotics and psychostimulants with high efficacy and few side effects. Toward this end, animal models are indispensable for use in genetic and chemical screens to identify sleep-wake modifiers. As a proof-of-concept study, we performed behavioral profiling of zebrafish treate

SUBMITTER: Nishimura Y 

PROVIDER: S-EPMC4630575 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature