Effect of vitamin D on MS activity by disease-modifying therapy class.

ABSTRACT:

Objective

To determine whether vitamin D status predicts disease activity in patients with multiple sclerosis (MS) taking interferon-β (IFN), glatiramer acetate (GA), and fingolimod (FTY).

Methods

Participants (n = 324) with relapsing-remitting MS on IFN (96), GA (151), or FTY (77) were identified from the Comprehensive Longitudinal Investigation of MS at Brigham and Women's Hospital (CLIMB) Study at the Partners MS Center. FTY-treated participants were analyzed separately because of differences in selection. Serum vitamin 25(OH)D concentration was adjusted for season. We evaluated the relationship between 25(OH)D tertile and time to relapse or gadolinium-enhancing lesion using a Cox model adjusted for age, sex, and disease duration.

Results

Higher 25(OH)D was associa

SUBMITTER: Rotstein DL 

PROVIDER: S-EPMC4630683 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature