Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial.

ABSTRACT:

Background

Generalised anxiety disorder (GAD) is a chronic and pervasive condition that generates high levels of psychological stress, and it is difficult to treat in the long term. Current pharmacotherapeutic options for GAD are in some cases only modestly effective, and may elicit undesirable side effects. Through targeted actions on the gamma-aminobutyric acid (GABA) pathway, the South Pacific medicinal plant kava (Piper methysticum) is a non-addictive, non-hypnotic anxiolytic with the potential to treat GAD. The evidence for the efficacy of kava for treating anxiety has been affirmed through clinical trials and meta-analyses. Recent research has also served to lessen safety concerns regarding the use of kava due to hepatotoxic risk, which is reflected in a recent German court o

SUBMITTER: Savage KM 

PROVIDER: S-EPMC4630875 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature