Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet.

ABSTRACT:

Introduction

Increased animal fat consumption is associated with increased premenopausal breast cancer risk in normal weight, but not overweight, women. This agrees with our previous findings in obesity-resistant BALB/c mice, in which exposure to a high saturated animal fat diet (HFD) from peripuberty through adulthood promoted mammary tumorigenesis. Epidemiologic and animal studies support the importance of puberty as a life stage when diet and environmental exposures affect adult breast cancer risk. In this study, we identified the effects of peripubertal exposure to HFD and investigated its mechanism of enhancing tumorigenesis.

Methods

Three-week-old BALB/c mice fed a low-fat diet (LFD) or HFD were subjected to 7,12-dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis.

SUBMITTER: Aupperlee MD 

PROVIDER: S-EPMC4630903 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature