Infection, vaccination, and childhood arterial ischemic stroke: Results of the VIPS study.

ABSTRACT:

Objectives

Minor infection can trigger adult arterial ischemic stroke (AIS) and is common in childhood. We tested the hypotheses that infection transiently increases risk of AIS in children, regardless of stroke subtype, while vaccination against infection is protective.

Methods

The Vascular Effects of Infection in Pediatric Stroke study is an international case-control study that prospectively enrolled 355 centrally confirmed cases of AIS (29 days-18 years old) and 354 stroke-free controls. To determine prior exposure to infections and vaccines, we conducted parental interviews and chart review.

Results

Median (interquartile range) age was 7.6 years for cases and 9.3 for controls (p = 0.44). Infection in the week prior to stroke, or interview date for controls, was r

SUBMITTER: Fullerton HJ 

PROVIDER: S-EPMC4631070 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature