Systemic thrombolysis in acute ischemic stroke patients with unruptured intracranial aneurysms.

ABSTRACT:

Objective

We sought to determine the safety of IV thrombolysis (IVT) in acute ischemic stroke (AIS) patients harboring unruptured intracranial aneurysm (UIA) in a multicenter study and a comprehensive meta-analysis of available case series.

Methods

We analyzed prospectively collected data from consecutive AIS patients treated with IVT during a 4-year period at 4 tertiary-care stroke centers. All patients routinely underwent CT or magnetic resonance angiography during hospitalization. The presence of UIA was documented on the basis of neuroradiology reports. Symptomatic intracranial hemorrhage (sICH) was defined as imaging evidence of ICH combined with an increase in NIH Stroke Scale score of ≥4 points. A systematic meta-analysis of case series reporting safety of IVT in AIS

SUBMITTER: Goyal N 

PROVIDER: S-EPMC4631074 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature