Sex Steroid Hormone Receptor Expression Affects Ovarian Cancer Survival.

ABSTRACT: BACKGROUND AND AIMS:Although most ovarian cancers express estrogen (ER), progesterone (PR), and androgen (AR) receptors, they are currently not applied in clinical decision making. We explored the prognostic impact of sex steroid hormone receptor protein and mRNA expression on survival in epithelial ovarian cancer. METHODS:Immunohistochemical stainings for ERα, ERβ, PR, and AR were assessed in relation to survival in 118 serous and endometrioid ovarian cancers. Expression of the genes encoding the four receptors was studied in relation to prognosis in the molecular subtypes of ovarian cancer in an independent data set, hypothesizing that the expression levels and prognostic impact may differ between the subtypes. RESULTS:Expression of PR or AR protein was associated with improved 5-year pr

SUBMITTER: Jonsson JM 

PROVIDER: S-EPMC4631098 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature