Bacterial calpains and the evolution of the calpain (C2) family of peptidases.
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ABSTRACT:
SUBMITTER: Rawlings ND
PROVIDER: S-EPMC4631099 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Bacterial calpains and the evolution of the calpain (C2) family of peptidases.
Biology direct 20151102
Homologues of calpain, often thought to be an essential, cytoplasmic, calcium-dependent cysteine endopeptidase found exclusively in eukaryotes, have been found in bacterial proteomes. The homologues lack calcium-binding sites, have differing domain architectures, and can be secreted or membrane-associated. Homologues are rare and occur in a minority of bacterial phyla and often in a minority of species in a genus. However, the differences in domain architecture argue against a recent, horizontal ...[more]
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