Drug disposition and modelling before and after gastric bypass: immediate and controlled-release metoprolol formulations.

ABSTRACT:

Aims

The aim of the present study was to evaluate the disposition of metoprolol after oral administration of an immediate and controlled-release formulation before and after Roux-en-Y gastric bypass (RYGB) surgery in the same individuals and to validate a physiologically based pharmacokinetic (PBPK) model for predicting oral bioavailability following RYGB.

Methods

A single-dose pharmacokinetic study of metoprolol tartrate 200 mg immediate release and controlled release was performed in 14 volunteers before and 6-8 months after RYGB. The observed data were compared with predicted results from the PBPK modelling and simulation of metoprolol tartrate immediate and controlled-release formulation before and after RYGB.

Results

After administration of metoprolol immediate a

SUBMITTER: Gesquiere I 

PROVIDER: S-EPMC4631175 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature