Expression of Th17 cell population regulatory cytokines in laryngeal carcinoma - Preliminary study.

ABSTRACT:

Aim of the study

Aim of the study was to evaluate the potential role of regulatory and proinflammatory cytokines IL-23 and IL-17 as Th17 lymphocyte activity markers in relation to invasiveness in laryngeal cancer.

Material and methods

The immunological analysis was conducted in 50 patients treated for squamous cell laryngeal carcinoma and 30 healthy volunteers as controls. The levels of IL-23 and IL-17 in supernatants of purified peripheral blood mononuclear cell cultures were determined by using the enzyme-linked immunosorbent assay (ELISA). The clinicomorphological criteria included pTNM, stage, G, and the total tumour front grading (TFG) score.

Results

Our data demonstrated higher concentrations of IL-23 in patients as compared to controls (p = 0.0001). No statisti

SUBMITTER: Kopta R 

PROVIDER: S-EPMC4631281 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature