Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.

ABSTRACT: Understanding the etiology of metastasis is very important in clinical perspective, since it is estimated that metastasis accounts for 90% of cancer patient mortality. Metastasis results from a sequence of multiple steps including invasion and migration. The early stages of metastasis are tightly controlled in normal cells and can be drastically affected by malignant mutations; therefore, they might constitute the principal determinants of the overall metastatic rate even if the later stages take long to occur. To elucidate the role of individual mutations or their combinations affecting the metastatic development, a logical model has been constructed that recapitulates published experimental results of known gene perturbations on local invasion and migration processes, and predict the eff

SUBMITTER: Cohen DP 

PROVIDER: S-EPMC4631357 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature