Phenotypic and molecular characterization of invasive serogroup W135 Neisseria meningitidis strains from 1990 to 2005 in Brazil.

ABSTRACT:

Objective

Neisseria meningitidis serogroup W135 has been associated with global outbreaks since the 2000 Hajj. Considering that N. meningitidis serogroup W135 is the third most prevalent serogroup isolated in Brazil in the last 10 years, and the possibility that the Hajj-related N. meningitidis serogroup W135 clone has been causing disease in Brazil, the present study characterized invasive N. meningitidis serogroup W135 isolates recovered in Brazil from 1990 to 2005.

Methods

The isolates were characterized by serotyping, PorA and PorB VR typing, FetA and 16S rRNA typing, multilocus sequence typing (MLST) and pulsed field gel electrophoresis (PFGE).

Results

Based on MLST, 73% of the isolates were clustered in one major clone of ST-11 complex/ET37 complex. Strains of t

SUBMITTER: Lemos AP 

PROVIDER: S-EPMC4631377 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature