Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues.

ABSTRACT:

Motivation

Global protein interaction network (interactome) analysis provides an effective way to understand the relationships between genes. Through this approach, it was demonstrated that the essential genes in yeast tend to be highly connected as well as connected to other highly connected genes. This is in contrast to the genes that are not essential, which share neither of these properties. Using a similar interactome-transcriptome approach, the topological features in the interactome of differentially expressed genes in lung squamous cancer tissues are assessed.

Results

This analysis reveals that the genes that are differentially elevated, as obtained from the microarray gene profiling data, in cancer are well connected, whereas the suppressed genes and randomly select

SUBMITTER: Wachi S 

PROVIDER: S-EPMC4631381 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature