High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention.

ABSTRACT:

Objective

To examine the performances of an alternative strategy to decide initiating BP-lowering drugs called Proportional Benefit (PB). It selects candidates addressing the inequity induced by the high-risk approach since it distributes the gains proportionally to the burden of disease by genders and ages.

Study design and setting

Mild hypertensives from a Realistic Virtual Population by genders and 10-year age classes (range 35-64 years) received simulated treatment over 10 years according to the PB strategy or the 2007 ESH/ESC guidelines (ESH/ESC). Primary outcomes were the relative life-year gain (life-years gained-to-years of potential life lost ratio) and the number needed to treat to gain a life-year. A sensitivity analysis was performed to assess the impact of chang

SUBMITTER: Marchant I 

PROVIDER: S-EPMC4631497 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature