Differential Involvement of the Dentate Gyrus in Adaptive Forgetting in the Rat.

ABSTRACT: How does the brain discriminate essential information aimed to be stored permanently from information required only temporarily, and that needs to be cleared away for not saturating our precious memory space? Reference Memory (RM) refers to the long-term storage of invariable information whereas Working Memory (WM) depends on the short-term storage of trial-unique information. Previous work has revealed that WM tasks are very sensitive to proactive interference. In order to prevent such interference, irrelevant old memories must be forgotten to give new ones the opportunity to be stabilized. However, unlike memory, physiological processes underlying this adaptive form of forgetting are still poorly understood. Here, we precisely ask what specific brain structure(s) could be responsible for

SUBMITTER: Joseph MA 

PROVIDER: S-EPMC4631520 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature