Volume changes and brain-behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure.

ABSTRACT: Children with prenatal alcohol exposure (PAE) may have cognitive, behavioral and brain abnormalities. Here, we compare rates of white matter and subcortical gray matter volume change in PAE and control children, and examine relationships between annual volume change and arithmetic ability, behavior, and executive function. Participants (n = 75 PAE/64 control; age: 7.1-15.9 years) each received two structural magnetic resonance scans, ~2 years apart. Assessments included Wechsler Intelligence Scale for Children (WISC-IV), the Child Behavior Checklist and the Behavior Rating Inventory of Executive Function. Subcortical white and gray volumes were extracted for each hemisphere. Group volume differences were tested using false discovery rate (q < 0.05). Analyses examined group-by-age interacti

SUBMITTER: Gautam P 

PROVIDER: S-EPMC4631525 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature