A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis.

ABSTRACT:

Purpose

Brain metastasis is the major cause of mortality among patients with melanoma. A molecular prognostic test that can reliably stratify patients at initial melanoma diagnosis by risk of developing brain metastasis may inform the clinical management of these patients.

Experimental design

We performed a retrospective, cohort-based study analyzing genome-wide and targeted microRNA expression profiling of primary melanoma tumors of three patient cohorts (n = 92, 119, and 45) with extensive clinical follow-up. We used Cox regression analysis to establish a microRNA-based signature that improves the ability of the current clinicopathologic staging system to predict the development of brain metastasis.

Results

Our analyses identified a 4-microRNA (miR-150-5p, miR-15b-5

SUBMITTER: Hanniford D 

PROVIDER: S-EPMC4631639 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature