Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

ABSTRACT:

Unlabelled

Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) profiling of small-molecule sensitivity has emerged as an unbiased method to assess the relationships between genetic or cellular features of CCLs and small-molecule response. Here, we developed annotated cluster multidimensional enrichment analysis to explore the associations between groups of small molecules and groups of CCLs in a new, quantitative sensitivity dataset. This analysis reveals insights into small-molecule mechanisms of action, and genomic features that associate with CCL response to small-molecule treatment. We are able to recapitulate known relationships between FDA-app

SUBMITTER: Seashore-Ludlow B 

PROVIDER: S-EPMC4631646 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature