MiR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer.

ABSTRACT:

Purpose

To investigate the involvement of hsa-miRNA-195-5p (miR-195) in progression and prognosis of human prostate cancer.

Experimental design

qRT-PCR was performed to detect miR-195 expression in both prostate cancer cell lines and clinical tissue samples. Its clinical significance was statistically analyzed. The roles of miR-195 and its candidate target gene, ribosomal protein S6 kinase, 70 kDa, polypeptide 1 (RPS6KB1) in prostate cancer progression were confirmed on the basis of both in vitro and in vivo systems.

Results

miR-195 downregulation in prostate cancer tissues was significantly associated with high Gleason score (P = 0.001), positive metastasis failure (P < 0.001), and biochemical recurrence (BCR, P < 0.001). Survival analysis identified miR-195 as an in

SUBMITTER: Cai C 

PROVIDER: S-EPMC4631653 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature