Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome.

ABSTRACT:

Background

The right ventricular outflow tract (RVOT) is acknowledged to be responsible for arrhythmogenesis in Brugada syndrome (BrS), but the pathophysiology remains controversial.

Objectives

This study assessed the substrate underlying BrS at post-mortem and in vivo, and the role for open thoracotomy ablation.

Methods

Six whole hearts from male post-mortem cases of unexplained sudden death (mean age 23.2 years) with negative specialist cardiac autopsy and familial BrS were used and matched to 6 homograft control hearts by sex and age (within 3 years) by random risk set sampling. Cardiac autopsy sections from cases and control hearts were stained with picrosirius red for collagen. The RVOT was evaluated in detail, including immunofluorescent stain for connexin-43 (C

SUBMITTER: Nademanee K 

PROVIDER: S-EPMC4631798 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature