Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico.

ABSTRACT: Liver cirrhosis (LC) is a chronic illness caused by inflammatory responses and progressive fibrosis. Globally, the most common causes of chronic liver disease include persistent alcohol abuse, followed by viral hepatitis infections and nonalcoholic fatty liver disease. However, regardless of the etiological factors, the susceptibility and degree of liver damage may be influenced by genetic polymorphisms that are associated with distinct ethnic and cultural backgrounds. Consequently, metabolic genes are influenced by variable environmental lifestyle factors, such as diet, physical inactivity, and emotional stress, which are associated with regional differences among populations. This Topic Highlight will focus on the genetic and environmental factors that may influence the metabolism of alc

SUBMITTER: Ramos-Lopez O 

PROVIDER: S-EPMC4631960 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature