LinkImpute: Fast and Accurate Genotype Imputation for Nonmodel Organisms.

ABSTRACT: Obtaining genome-wide genotype data from a set of individuals is the first step in many genomic studies, including genome-wide association and genomic selection. All genotyping methods suffer from some level of missing data, and genotype imputation can be used to fill in the missing data and improve the power of downstream analyses. Model organisms like human and cattle benefit from high-quality reference genomes and panels of reference genotypes that aid in imputation accuracy. In nonmodel organisms, however, genetic and physical maps often are either of poor quality or are completely absent, and there are no panels of reference genotypes available. There is therefore a need for imputation methods designed specifically for nonmodel organisms in which genomic resources are poorly developed

SUBMITTER: Money D 

PROVIDER: S-EPMC4632058 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature