TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling.

ABSTRACT:

Objective

Failure to properly dispose of glucose in response to insulin is a serious health problem, occurring during obesity and is associated with type 2 diabetes development. Insulin-stimulated glucose uptake is facilitated by the translocation and plasma membrane fusion of vesicles containing glucose transporter 4 (GLUT4), the rate-limiting step of post-prandial glucose disposal.

Methods

We analyzed the role of Tusc5 in the regulation of insulin-stimulated Glut4-mediated glucose uptake in vitro and in vivo. Furthermore, we measured Tusc5 expression in two patient cohorts.

Results

Herein, we report that TUSC5 controls insulin-stimulated glucose uptake in adipocytes, in vitro and in vivo. TUSC5 facilitates the proper recycling of GLUT4 and other key trafficking prot

SUBMITTER: Beaton N 

PROVIDER: S-EPMC4632119 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature