Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.

ABSTRACT:

Objective

Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss- and gain-of-function studies have generated confounding data regarding the role of this sirtuin on energy and glucose homeostasis, leaving unclear whether activation or inhibition of SIRT6 may be beneficial for the treatment of obesity and/or T2DM.

Methods

To address these issues, we developed and studied a novel mouse model designed to produce eutopic and physiological overexpression of SIRT6 (Sirt6BAC mice). These mutants and their controls underwent several metabolic analyses. These include whole-blood reverse phase high-perfor

SUBMITTER: Anderson JG 

PROVIDER: S-EPMC4632175 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature