The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle.

ABSTRACT:

Objective

Physical activity and circadian rhythms are well-established determinants of human health and disease, but the relationship between muscle activity and the circadian regulation of muscle genes is a relatively new area of research. It is unknown whether muscle activity and muscle clock rhythms are coupled together, nor whether activity rhythms can drive circadian gene expression in skeletal muscle.

Methods

We compared the circadian transcriptomes of two mouse hindlimb muscles with vastly different circadian activity patterns, the continuously active slow soleus and the sporadically active fast tibialis anterior, in the presence or absence of a functional skeletal muscle clock (skeletal muscle-specific Bmal1 KO). In addition, we compared the effect of denervation on

SUBMITTER: Dyar KA 

PROVIDER: S-EPMC4632177 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature