Differential expression analysis of human endogenous retroviruses based on ENCODE RNA-seq data.

ABSTRACT:

Background

Human endogenous retroviruses (HERVs) are flanked by long terminal repeats (LTRs), which possess promoter activity and can therefore influence the expression of neighboring genes. HERV involvement in different types of cancer has already been thoroughly documented. However, so far there has been no systematic study of HERV expression patterns in a multitude of cell types in health and disease. In particular, the publication of the comprehensive ENCODE dataset has already facilitated many gene expression studies, but none so far focusing exclusively on HERVs.

Results

We present a comprehensive differential analysis of HERV expression based on ENCODE Tier 1 and Tier 2 RNA-seq data produced by Cold Spring Harbor Laboratories and the California Institute of Technology

SUBMITTER: Haase K 

PROVIDER: S-EPMC4632268 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature