RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging.

ABSTRACT: Receptor-associated coactivator 3 (RAC3) is a nuclear receptor coactivator usually overexpressed in tumors that exerts oncogenic functions in the cytoplasm and the nucleus. Although as part of its oncogenic actions it was previously identified as an inhibitor of apoptosis and autophagy, its expression is required in order to preserve the pluripotency and embryonic stem cell self-renewal. In this work we investigated its role in cellular senescence. We found that RAC3 overexpression in the nontumoral HEK293 cells inhibits the premature senescence induced by hydrogen peroxide or rapamycin. The mechanism involves not only the inhibition of autophagy early induced by these stimuli in the pathway to senescence, but also the increase in levels and nuclear localization of both the cell cycle supp

SUBMITTER: Fernandez Larrosa PN 

PROVIDER: S-EPMC4632280 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature