Treatment of Brain AVMs (TOBAS): study protocol for a pragmatic randomized controlled trial.

ABSTRACT:

Background

The management of unruptured brain arteriovenous malformation (AVM) patients remains controversial. Furthermore, curative attempts to treat ruptured AVM patients have not been questioned so far, and there is a lack of prospective data on clinical results according to treatment modality. Endovascular treatment is often used aiming to improve the safety or efficacy of surgery or radiation therapy, but benefits have never been documented in a trial. A care trial context is needed to evaluate interventions at the same time they are practised.

Methods/trial design

TOBAS is a pragmatic, prospective, multicenter, randomized, controlled trial and registry which offers a care trial context for brain AVM patients, including surgical resection, radiosurgery or endovascular e

SUBMITTER: Darsaut TE 

PROVIDER: S-EPMC4632683 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature