Crystal structures of CaSiO₃ polymorphs control growth and osteogenic differentiation of human mesenchymal stem cells on bioceramic surfaces.

ABSTRACT: The repair and replacement of damaged or diseased human bone tissue requires a stable interface between the orthopedic implant and living tissue. The ideal material should be both osteoconductive (promote bonding to bone) and osteoinductive (induce osteogenic differentiation of cells and generate new bone). Partially resorbable bioceramic materials with both properties are developed by expensive trial-and-error methods. Structure-reactivity relationships for predicting the osteoinductive properties of ceramics would significantly increase the efficiency of developing materials for bone tissue engineering. Here we propose the novel hypothesis that the crystal structure of a bioceramic controls the release rates, subsequent surface modifications due to precipitation of new phases, and thus,

SUBMITTER: Zhang N 

PROVIDER: S-EPMC4633021 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature