Role of Tellurite Resistance Operon in Filamentous Growth of Yersinia pestis in Macrophages.

ABSTRACT:

Background

Yersinia pestis initiates infection by parasitism of host macrophages. In response to macrophage infections, intracellular Y. pestis can assume a filamentous cellular morphology which may mediate resistance to host cell innate immune responses. We previously observed the expression of Y. pestis tellurite resistance proteins TerD and TerE from the terZABCDE operon during macrophage infections. Others have observed a filamentous response associated with expression of tellurite resistance operon in Escherichia coli exposed to tellurite. Therefore, in this study we examine the potential role of Y. pestis tellurite resistance operon in filamentous cellular morphology during macrophage infections.

Principal findings

In vitro treatment of Y. pestis culture with sodium te

SUBMITTER: Ponnusamy D 

PROVIDER: S-EPMC4633105 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature