A Peptide to Reduce Pulmonary Edema in a Rat Model of Lung Transplantation.

ABSTRACT:

Background

Despite significant advances in organ preservation, surgical techniques and perioperative care, primary graft dysfunction is a serious medical problem in transplantation medicine in general and a specific problem in patients undergoing lung transplantation. As a result, patients develop lung edema, causing reduced tissue oxygenation capacity, reduced lung compliance and increased requirements for mechanical ventilatory support. Yet, there is no effective strategy available to protect the grafted organ from stress reactions induced by ischemia/reperfusion and by the surgical procedure itself.

Methods

We assessed the effect of a cingulin-derived peptide, XIB13 or a random peptide in an established rat model of allogeneic lung transplantation. Donor lungs and recipie

SUBMITTER: Schossleitner K 

PROVIDER: S-EPMC4633234 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature