Calcium intake, polymorphisms of the calcium-sensing receptor, and recurrent/aggressive prostate cancer.

ABSTRACT:

Purpose

To assess whether calcium intake and common genetic variants of the calcium-sensing receptor (CASR) are associated with either aggressive prostate cancer (PCa) or disease recurrence after prostatectomy.

Methods

Calcium intake at diagnosis was assessed, and 65 common single-nucleotide polymorphisms (SNPs) in CASR were genotyped in 886 prostatectomy patients. We investigated the association between calcium intake and CASR variants with both PCa recurrence and aggressiveness (defined as Gleason score ≥4 + 3, stage ≥pT3, or nodal-positive disease).

Results

A total of 285 men had aggressive disease and 91 experienced recurrence. A U-shaped relationship between calcium intake and both disease recurrence and aggressiveness was observed. Compared to the middle quintil

SUBMITTER: Binder M 

PROVIDER: S-EPMC4633306 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature