Relationship of insulin dynamics to body composition and resting energy expenditure following weight loss.

ABSTRACT:

Objective

To examine associations of baseline insulin dynamics with changes in body composition and resting energy expenditure (REE) following weight loss.

Methods

Twenty-one participants with overweight or obesity achieved 10-15% weight loss and then received 3 weight loss maintenance diets (high-carbohydrate, moderate-carbohydrate, and low-carbohydrate) in random order, each for 4 weeks. Body composition was measured at baseline and after weight loss. Insulin 30 min after glucose consumption (insulin-30; insulin response), C-peptide deconvolution analysis, HOMA, hepatic insulin sensitivity (IS), and REE were assessed at baseline and after each maintenance diet.

Results

Insulin-30, but not maximal insulin secretion, hepatic IS, or HOMA, predicted changes in fat mass

SUBMITTER: Hron BM 

PROVIDER: S-EPMC4633340 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature