Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk.

ABSTRACT:

Background

A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored.

Methods

We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium.

Results

Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10(-4); OR, 1.04; 95% confidence interval (CI), 1.02-1.07] and rs77928427 (P = 1.86 × 10(-4); OR, 1.04; 95% CI, 1.02-1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional

SUBMITTER: Guo X 

PROVIDER: S-EPMC4633342 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature