Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Existing literature suggests that metformin, the most commonly used biguanide, may lower colorectal cancer risk. Because most colorectal cancers originate in precancerous adenomas, we examined whether metformin use lowered colorectal adenoma risk after polypectomy in patients with type-2 diabetes.

Methods

Retrospective cohort study of 40- to 89-year-old Kaiser Permanente Northern California patients who had type 2 diabetes, and ≥1 adenoma detected at baseline colonoscopy during 2000 to 2009 and a repeat colonoscopy 1 to 10 years from baseline adenoma diagnosis through 2012. Cox models evaluated the association between metformin use during follow-up and subsequent adenoma diagnoses, controlling for age, race/ethnicity, sex, body mass index, and repeat examination i

SUBMITTER: Marks AR 

PROVIDER: S-EPMC4633388 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature