Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior.

ABSTRACT:

Background

Stress exposure is one of the greatest risk factors for psychiatric illnesses like major depressive disorder and posttraumatic stress disorder. However, not all individuals exposed to stress develop affective disorders. Stress resilience, the ability to experience stress without developing persistent psychopathology, varies from individual to individual. Enhancing stress resilience in at-risk populations could potentially protect against stress-induced psychiatric disorders. Despite this fact, no resilience-enhancing pharmaceuticals have been identified.

Methods

Using a chronic social defeat (SD) stress model, learned helplessness (LH), and a chronic corticosterone (CORT) model in mice, we tested if ketamine could protect against depressive-like behavior. Mice wer

SUBMITTER: Brachman RA 

PROVIDER: S-EPMC4633406 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature