Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors.

ABSTRACT: Although family B G protein-coupled receptors (GPCRs) contain only 15 members, they play key roles in transmembrane signal transduction of hormones. Family B GPCRs are drug targets for developing therapeutics for diseases ranging from metabolic to neurological disorders. Despite their importance, the molecular mechanism of activation of family B GPCRs remains largely unexplored due to the challenges in expression and purification of functional receptors to the quantity for biophysical characterization. Currently, there is no crystal structure available of a full-length family B GPCR. However, structures of key domains, including the extracellular ligand binding regions and seven-helical transmembrane regions, have been solved by X-ray crystallography and NMR, providing insights into the me

SUBMITTER: Culhane KJ 

PROVIDER: S-EPMC4633518 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature