Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles.

ABSTRACT: The development and progression of oral cavity squamous cell carcinoma (OSCC) involves complex cellular mechanisms that contribute to the low five-year survival rate of approximately 20% among diagnosed patients. However, the biological processes essential to tumor progression are not completely understood. Therefore, detecting alterations in the salivary proteome may assist in elucidating the cellular mechanisms modulated in OSCC and improve the clinical prognosis of the disease. The proteome of whole saliva and salivary extracellular vesicles (EVs) from patients with OSCC and healthy individuals were analyzed by LC-MS/MS and label-free protein quantification. Proteome data analysis was performed using statistical, machine learning and feature selection methods with additional functional

SUBMITTER: Winck FV 

PROVIDER: S-EPMC4633731 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature