Oncolytic measles virus efficacy in murine xenograft models of atypical teratoid rhabdoid tumors.

ABSTRACT:

Background

Atypical teratoid rhabdoid tumor (AT/RT) is a rare, highly malignant pediatric tumor of the central nervous system that is usually refractory to available treatments. The aggressive growth, propensity to disseminate along the neuroaxis, and young age at diagnosis contribute to the poor prognosis. Previous studies have demonstrated the efficacy of using oncolytic measles virus (MV) against localized and disseminated models of medulloblastoma. The purpose of this study was to evaluate the oncolytic potential of MV in experimental models of AT/RT.

Methods

Following confirmation of susceptibility to MV infection and killing of AT/RT cells in vitro, nude mice were injected with BT-12 and BT-16 AT/RT cells stereotactically into the caudate nucleus (primary tumor model)

SUBMITTER: Studebaker AW 

PROVIDER: S-EPMC4633925 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature