Ontology highlight
ABSTRACT:
SUBMITTER: Gama-Norton L
PROVIDER: S-EPMC4634136 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature communications 20151014
Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the haemogenic endothelium/HSC on Jag1-mediated Notch1 signalling. How Notch1 distinguishes and executes these different programmes in response to particular ligands is poorly understood. By using two Notch1 activation trap mouse models with different sensitivity, here we show tha ...[more]