The genetic match between vaccine strains and circulating seasonal influenza A viruses in Vietnam, 2001-2009.

ABSTRACT:

Background

Vietnam is currently developing domestic capability to manufacture influenza vaccines but information on the genetic and antigenic characteristics of locally circulating seasonal influenza viruses is limited. To assess the relevance of WHO recommended vaccine strains to the situation in Vietnam, we analyzed the genetic relatedness of the hemagglutinin (HA) gene of seasonal influenza A viruses circulating in Vietnam from 2001 to 2009 to WHO recommended vaccine strains over the same period.

Methods and principal findings

We sequenced the HA gene of 32 H1N1 and 44 H3N2 seasonal influenza A isolates from laboratory-based sentinel surveillance sites in Hanoi from 2001 to 2005 and from a national influenza surveillance system from 2005 to 2009. H1 and H3 HA phylogenetic

SUBMITTER: Vuong CD 

PROVIDER: S-EPMC4634303 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature