Assessing atrophy measurement techniques in dementia: Results from the MIRIAD atrophy challenge.

ABSTRACT: Structural MRI is widely used for investigating brain atrophy in many neurodegenerative disorders, with several research groups developing and publishing techniques to provide quantitative assessments of this longitudinal change. Often techniques are compared through computation of required sample size estimates for future clinical trials. However interpretation of such comparisons is rendered complex because, despite using the same publicly available cohorts, the various techniques have been assessed with different data exclusions and different statistical analysis models. We created the MIRIAD atrophy challenge in order to test various capabilities of atrophy measurement techniques. The data consisted of 69 subjects (46 Alzheimer's disease, 23 control) who were scanned multiple (up to tw

SUBMITTER: Cash DM 

PROVIDER: S-EPMC4634338 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature