Multiple comparisons analysis of serological data from an area of low Plasmodium falciparum transmission.

ABSTRACT:

Background

As a nation reduces the burden of falciparum malaria, identifying areas of transmission becomes increasingly difficult. Over the past decade, the field of utilizing malaria serological assays to measure exposure has grown rapidly, and a variety of serological methods for data acquisition and analysis of human IgG against falciparum antigens are available. Here, different immunoassays and statistical methods are utilized to analyse samples from a low transmission setting and directly compare the estimates generated.

Methods

A subset of samples (n = 580) from a 2012 Haitian nationwide malaria survey was employed as sample population of low falciparum endemicity. In addition to the Haitian samples, samples from 247 US residents were used as a reference population of

SUBMITTER: Rogier E 

PROVIDER: S-EPMC4634594 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature